Wipe-off test device
AssigneeMiles Laboratories, Inc.
InventorShuenn-tzong Chen
Life of this patent
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Abstract
A test device for determining the presence of a substance in a test sample is disclosed, as well as methods for making and using it. The device comprises a support member having a reagent layer affixed to it which contains a reagent system which produces a detectable response in the presence of the analyte. The reagent layer has an upper layer affixed to the side opposite the support member. The upper layer comprises a polymer which is at least partially crosslinked. The method of use comprises contacting the device with the test sample, wiping the upper layer free of test sample residue, and observing a detectable response.
Claims9
A test device for determining the presence of a substance in a test sample comprising a carrier matrix having an upper and lower layer, the lower layer being affixed to a support member;
- in which the upper layer is porous to water, but impermeable to proteins and colored pigment contained in the test sample, and the lower layer comprises a reagent system capable of producing a detectable response in the presence of the substance;
- the improvement wherein the upper layer consists essentially of a partially crosslinked polymer of gelatin, agarose, alginic acid, a salt of alginic acid, or mixtures thereof.
A test device for determining the presence of a substance in a test sample, the device comprising:
- a carrier matrix having a upper layer and a reagent system layer affixed to the upper layer, the reagent system layer comprising a bibulous material incorporated with a reagent system capable of producing a detectable response in the presence of the substance and the upper layer comprising a continuous film of a partially crosslinked polymer of gelatin, agarose, alginic acid, a salt of alginic acid, or mixtures thereof;
- and
- a support member having the reagent system layer of the carrier matrix affixed thereto.
A method for preparing a test device for determining the presence of a substance in a test sample, the method comprising the steps of:
- incorporating a bibulous material with a reagent system to form a reagent system layer having an upper and lower side;
- coating the upper side of the reagent system layer with an aqueous solution of a polymer of gelatin, agarose, alginic acid, a salt of alginic acid, or mixtures thereof, and a crosslinking agent therefor, to form a partially crosslinked upper layer and;
- affixing the lower side of the reagent system layer to a support member.
Dependencies are inferred from the claim text.