Process for detecting pathogens
AssigneeBoehringer Mannheim GmbH
InventorsFranz Keller, Hans Hennemann
Life of this patent
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Abstract
Process and device for the detection of pathogens, such as bacteria, fungi and viruses, in blood in the presence of an anticoagulant agent. The pathogen is separated in an extracorporeal circulation of the blood with a biocompatible adsorbent which selectively binds the pathogen and thereafter detects by bacteriological, mycological, virological or electron microscopic methods.
Claims19
Process for the detection of pathogens, such as bacteria, fungi and viruses, in blood in the presence of an anticoagulant agent which comprises:
- separating a pathogen in an extracorporeal circulation of the blood, by passing the blood through a sterile adsorbent which is nontoxic and inert to blood and which selectively binds the pathogen while the blood passes the adsorbent;
- and thereafter detecting the adsorbed pathogen while still culturable.
Process for detecting the presence of a pathogen selected from the group consisting of bacteria, fungi and viruses, in blood, as a means of early medical diagnosis of sepsis which comprises,
- extracorporeally circulating blood under investigation in the presence of an anticoagulant through a bed of a sterile particulate material which is nontoxic and inert to blood and effective to selectively bind a pathogen in the blood while the blood passes the adsorbent,
- permitting said material to bind any pathogen in the blood,
- recovering the material with any pathogen found or immobilized thereon while the pathogen is still culturable, and
- analyzing the material to detect any bound or immobilized pathogen.
Dependencies are inferred from the claim text.