Solidified pharmaceutical composition comprising cell wall skeleton
OwnerYuichi Yamamura, Ichiro Azuma +2inventors
InventorsYuichi Yamamura, Ichiro Azuma, Katsusuke Ennyu, Osamu Aoki
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Abstract
A stable, storable pharmaceutical composition is provided which comprises a dehydrated solid mixture of microbial cell wall skeleton, vehicle oil, suspending agent and dispersing agent; wherein said microbial cell wall skeleton has adjuvant and antitumor activity. The composition is easily prepared, stable to long term storage, and easily reconstituted to form a homogeneous suspension which retains high potency.
Claims8
A stable, storable pharmaceutical composition, which comprises a dehydrated solid mixture of Nocardia rubra cell wall skeleton, vehicle oil comprising squalene or liquid petrolatum, suspending agent, and dispersing agent comprising mannitol, sorbitol or glucose;
- wherein said cell wall skeleton has anti-tumor activity;
- wherein said cell wall skeleton is present in an amount effective to exhibit anti-tumor activity;
- wherein said vehicle oil is present in an amount less than 8 mg and effective to stimulate the anti-tumor activity of said cell wall skeleton;
- wherein said suspending agent is present in an amount less than 1 mg and effective for the preparation of an aqueous suspension of said cell wall skeleton and said vehicle oil;
- and wherein said dispersing agent is present in an amount less than 56 mg and effective to render an aqueous suspension of said cell wall skeleton, said vehicle oil and said suspending agent isotonic.
Dependencies are inferred from the claim text.