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US 4,543,251 AGranted
Gel preparations for external application
AssigneeToko Yakuhin Industry Co., Ltd.
InventorTakuzo Kamishita
Life of this patent
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Abstract
A gel preparation for external application by being prepared from diclofenac sodium as the active ingredient, water, lower alkanols and glycols as medium, a carboxyvinyl polymer as gelating agent, a weak basic substances and optionally adding peppermint oil, l-menthol or salicylic acid ester as auxiliary agent.
Claims7
A gel preparation for external application comprising diclofenac sodium as the active ingredient and present in amount of 0.3 to 3.0% by weight;
- a medium comprising water, a lower alkanol selected from the group consisting of methanol, ethanol, iso-propanol, butanol;
- and a glycol selected from the group consisting of ethylene glycol, propylene glycol and 1,3-butylene glycol, the medium being present in an amount at least sufficient to dissolve the active ingredient, the ratio of water to the combination of the lower alkanol and glycol being from about 8:2 to 4:6;
- a carboxyvinyl polymer selected from the group consisting of the hydrophilic polymers obtained by polymerization of acrylic acid, and present in an amount sufficient to gel the preparation;
- and an aliphatic amine, present in an amount sufficient to adjust the pH to about 6-8.
1 more element
Dependencies are inferred from the claim text.