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US 4,543,211 AGranted
Conjugate having cytotoxicity and process for the preparation thereof
AssigneeTeijin Limited
InventorsYoshinori Kato, Naoji Umemoto, Takeshi Hara, Yutaka Tsukada, Hidematsu Hirai
Life of this patent
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Abstract
A conjugate having cytotoxicity prepared by covalently binding a polymer which has cytotoxic substances linked to its side chains and a reactive group at its terminal to an immunoglobulin, or its fragment, which is capable of selectively binding to a particular antigen possessed by cells to be killed.
Claims11
A conjugate having cytotoxicity comprising:
- (1) an immunoglobulin or a fragment, which is capable of selectively binding to a particular antigen possessed by a cell to be killed, and covalently bound thereto, via a carbonyl group at the amino terminal of a peptide polymer, by means of a bridge having at least one sulfur atom and a divalent linking group, (2) a peptide polymer having cytotoxic substances covalently bound to its side chain and having only one reactive group capable of covalently binding to said immunoglobulin, or its fragment, said reactive group being at one terminal of said polymer, and wherein said polymer is not an immunoglobulin.
Dependencies are inferred from the claim text.