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US 4,542,236 AGranted
Process for preparing optically active phenylalanine
AssigneeNippon Kayaku Kabushiki Kaisha
InventorsYasuhisa Tashiro, Shigeru Aoki
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AssigneeNippon Kayaku Kabushiki Kaisha
InventorsYasuhisa Tashiro, Shigeru Aoki
Estimating the term…
The present invention relates to a process for preparing optically active phenylalanine which comprises resolving mixture of a complex of D-phenylalanine and optically active mandelic acid and a complex of L-phenylalanine and optically active mandelic acid in a solvent containing hydrochloric acid, carboxylic acid, phosphoric acid or a salt thereof to obtain the complex having lower solubility, and removing said optically active mandelic acid from the obtained complex to obtain an optically active phenylalanine. In the case of resolving DL-phenylalanine by the process according to the present invention, the amount of mother liquor used in resolution can be made to about 1/2 to 1/6 as compared to the amount of mother liquor of which the acidic compound or the salt thereof is not used in the resolution. Accordingly, the process according to the present invention is extremely profitable as an industrial process for producing an optically active phenylalanine.
A process for preparing optically active phenylalanine, which comprises resolving the mixture of a complex of D-phenylalanine and optically active mandelic acid and a complex of L-phenylalanine and optically active mandelic acid in a solvent containing hydrochloric acid, carboxylic acid, phosphoric acid or a salt thereof to obtain the complex having lower solubility, and removing said optically active mandelic acid from the obtained complex to obtain optically active phenylalanine.
Dependencies are inferred from the claim text.