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US 4,542,228 AGranted
4-Hydroxy-furochromone intermediates for antiathersclerotic compounds
AssigneeThe Upjohn Company
InventorRonald B. Gammill
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Abstract
The present specification provides intermediates for novel analogs of khellin, a natural product, which are useful in the treatment and prevention of atherosclerosis. Particularly, the present disclosure provides novel 5H-furo[3,2-g]-benzopyran-5-ones substituted at the nine position by methoxy and substituted at the four position by hydroxy.
Claims5
A fuorochormone of formula I
- wherein n is zero, one or two;
- wherein R.sub.2 is C.sub.1 -C.sub.6 alkyl or PhX;
- wherein (PhX) is phenyl substituted by zero to 3 of the following:
- (a) (C.sub.1 -C.sub.4)alkyl,
- (b) chloro,
- (c) fluoro,
- (d) bromo,
- (e) nitro,
- (f) trifluoromethyl;
- or
- (g) OR.sub.5 ;
- wherein R.sub.5 is
- (a) hydrogen, or
- (b) (C.sub.1 -C.sub.4)alkyl;
- wherein R.sub.3 is hydrogen or --O--CO--R.sub.4, wherein R.sub.4 is C.sub.1 -C.sub.4 alkyl;
- with the proviso that R.sub.3 is --O--CO--R.sub.4 only when n is zero and with a further proviso that when R.sub.2 is PhX n is zero and R.sub.3 is hydrogen.
13 more elements
Dependencies are inferred from the claim text.