Method for preparing 8-acylthio-1,2,3,4,5,6-hexahydro-2,6-methano-3,6(e),11(a)-trimethyl-3-be nzazocines
AssigneeWako Pure Chemical Industries, Ltd.
InventorsMikio Hori, Hajime Fujimura
Life of this patent
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Abstract
A method for preparing 8-acylthio-1,2,3,4,5,6-hexahydro-2,6-methano-3,6(e),11(a)-trimethyl-3-benz azocines represented by general formula (I) below ##STR1## wherein R represents an alkyl group, a phenyl group or a heterocyclic group, which comprises reacting 1,2,3,4,5,6-hexahydro-2,6-methano-3,6(e),11(a)-trimethyl-3-benzazocine represented by the formula (II) below ##STR2## or its salt with chlorosulfonic acid, heating the reaction product in the presence of a reducing agent, and reacting the reaction mixture with an acyl halide represented by the general formula (III) RCOX (III) wherein R has the same meaning as defined above and X represents a halogen atom is disclosed.
Claims24
A method for preparing 8-acylthio-1,2,3,4,5,6-hexahydro-2,6-methano-3,6(e),11(a)-trimethyl-3-benz azocines represented by formula (I) below:
- ##STR12## wherein R represents an alkyl group having 1 to 10 carbon atoms, a phenyl group or a 5- or 6-membered heterocyclic group wherein the hetero atom is a nitrogen atom or a nitrogen atom and one element selected from the group consisting of a nitrogen atom, a sulfur atom and an oxygen atom, which comprises reacting 1,2,3,4,5,6-hexahydro-2,6-methano-3,6(e),11(a)-trimethyl-3-benzazocine represented by formula (II) below:
- ##STR13## or its salt with chlorosulfonic acid, heating the reaction product in the presence of a reducing agent, and reacting the reaction mixture with an acyl halide represented by formula (III)
- RCOX (III)
- wherein R has the same meaning as defined above and X represents a halogen atom.
Dependencies are inferred from the claim text.