Process for the manufacture of heptakis-[2,6-di-O-methyl]-beta-cyclodextrin
AssigneeConsortium fur Elektrochemische Industrie GmbH
InventorsJozsef Szejtli, Andras Liptak, Pal Nanasi, Peter Fugedi, Ildiko Jodal, Lili Kandra, Lorant Janossy
Life of this patent
Estimating the term…
Abstract
The invention relates to a process for the manufacture of heptakis-[2,6-di-O-methyl]-beta-cyclodextrin by methylating beta-cyclodextrin in an organic phase wherein beta-cyclodextrin is methylated with dimethylsulfate in the presence of an alkalihydroxide at temperatures of from -10.degree. to 0.degree. C.
Claims10
In a process for the manufacture of heptakis-[2,6-di-O-methyl]-beta-cyclodextrin by methylating beta cyclodextrin in an organic medium, the improvement comprising the step of methylating beta-cyclodextrin with dimethylsulfate in amounts of from 15 to 25 moles per 1 mole of beta-cyclodextrin in the presence of an alkalihydroxide, wherein said alkalihydroxide is applied in at least an equimolar amount calculated on the amount of OH-groups to be methylated;
- at temperatures of from -10.degree. to 0.degree. C.
Dependencies are inferred from the claim text.