1-.beta.-D-Arabinofuranosyl-(E)-5-(2-halogenovinyl)-uracil-5'-phosphate, preparation thereof and use thereof
AssigneeYamasa Shoyu Kabushiki Kaisha
InventorsShinji Sakata, Haruhiko Machida
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Abstract
1-.beta.-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil-5'-phosphates of the formula (I): ##STR1## and wherein X is halogen, pharmaceutically acceptable salts thereof, are produced by phosphorylation of the non-phosphorylated precursors of the compounds (I), and are useful as anti-viral agents.
Claims9
A 1-.beta.-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)-uracil-5'-phosphate of the formula (I):
- ##STR4## wherein X represents halogen, or a pharmaceutically acceptable salt thereof.
A composition which exhibits activity against a DNA virus that induces deoxypyrimidine nucleoside kinase after infection by the virus, which composition comprises an anti-DNA virus effective amount of a compound of the formula (I) below or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier:
- ##STR5## wherein X represents halogen.
A composition according to claim 3 or claim 6, which is an anti-herpes virus agent.
A composition according to claim 3 or claim 6, which is an anti-varicella-zoster virus agent.
Dependencies are inferred from the claim text.