7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease

A compound having the structural formula ##STR15## and including all stereoisomers thereof, wherein A is --CH.dbd.CH--, or --(CH.sub.2).sub.2 --;

• y is 0 to 4;
• m is 0 to 8;
• n is 1 to 4;
• p is 1 to 12;
• q is 0 to 5;
• R is hydrogen, lower alkyl, alkali metal or tri(hydroxymethyl)aminomethane;
• and R.sup.1 is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, wherein the term lower alkyl or alkyl by itself or as part of another group contains 1 to 12 carbons and is unsubstituted or substituted with halo, trifluoromethyl, aryl, alkoxy, haloaryl, alkyl-aryl cycloalkyl or alkylcycloalkyl;
• the term aryl by itself or as part of another group contains 6 to 10 carbons and is unsubstituted or substituted with 1 or 2 lower alkyl groups, 1 or 2 halogens and/or 1 or 2 lower alkoxy groups;
• the term cycloalkyl by itself or as part of another group contains 3 to 12 carbons and is unsubstituted or substituted with 1 or 2 halogens, 1 or 2 lower alkyl groups and/or 1 or 2 lower alkoxy groups;
• the term (CH.sub.2).sub.m includes 0 to 8 carbons in the normal chain, the term (CH.sub.2).sub.n includes 1 to 4 carbons in the normal chain, the term (CH.sub.2).sub.y includes 0 to 4 carbons in the normal chain, the term (CH.sub.2).sub.p includes 1 to 12 carbons in the normal chain, and the term (CH.sub.2).sub.q includes 0 to 5 carbons in the normal chain;
• and the terms (CH.sub.2).sub.y, (CH.sub.2).sub.m, (CH.sub.2).sub.n, (CH.sub.2).sub.p and (CH.sub.2).sub.q may be unsubstituted or include one or more lower alkyl substituents.