Methods for changing calcium metabolism within the cells of a mammal
AssigneeThe Ohio State University Research Foundation
InventorsDonald T. Witiak, Ralf G. Rahwan
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Abstract
2-alkyl-5,6 alkylenedioxyindenes and indane-1-di- or tri- alkylammonium salts are useful as calcium antagonists, for example in arrhythmia. The compounds are prepared from the known corresponding 2,5,6-substituted indene-1-1dimethylammonium salts by alkylation and/or hydrogenation.
Claims24
A method for treating a mammal having a condition selected from the group consisting of arrhythmia, hypertension, constriction of the coronary artery and angina pectoris, which method comprises administering to said mammal from about 0.25 to about 10 mg/kg. body weight of said mammal of a pharmaceutically acceptable 2-alkyl-5,6-dialkoxy-indene-1-trialkylammonium salt of the Formula II ##STR1## wherein the two R.sub.1 groups together form an alkylene group of 1 to 3 carbon atoms, R.sub.2 is an alkyl group of 1 to about 8 carbon atoms, each R.sub.3 independently is an alkyl group of 1 to 3 carbon atoms and X is an anion.
A method for treating a mammal having a condition selected from the group consisting of arrhythmia, hypertension, constriction of the coronary artery and angina pectoris, which method comprises administering to said mammal from about 0.25 to about 10 mg/kg. body weight of said mammal of a cis 2-alkyl-5,6-dialkoxy-1-dialkylaminoindane of the formula ##STR2## wherein the two R.sub.1 groups together form an alkylene group of 1 to 3 carbon atoms, R.sub.2 is an alkyl group of 1 to about 8 carbon atoms and each R.sub.3 independently is an alkyl group of 1 to 3 carbon atoms.
A method for treating a mammal having a condition selected from the group consisting of arrhythmia, hypertension, constriction of the coronary artery and angina pectoris, which method comprises administering to said mammal from about 0.25 to about 10 mg/kg. body weight of said mammal of a cis 2-alkyl-5,6-dialkoxyindane-1-trialkylammonium salt of the Formula ##STR3## wherein the two R.sub.1 groups together form an alkylene group of 1 to 3 carbon atoms, R.sub.2 is an alkyl group of 1 to about 8 carbon atoms, each R.sub.3 independently is an alkyl group of 1 to 3 carbon atoms and X.sup.- is a pharmaceutically-acceptable anion.
Dependencies are inferred from the claim text.