Tetrahydrothienyl substituted ethers
AssigneeE. R. Squibb & Sons, Inc.
InventorJagabandhu Das
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Abstract
Tetrahydrothienyl substituted ethers are provided having the structural formula ##STR1## wherein A is (CH.sub.2).sub.2, CH.dbd.CH or a single bond, m is 1 to 5, B is a single bond or CH.dbd.CH, n is 1 to 4, X is O or ##STR2## wherein n' is 0, 1 or 2, R is H, lower alkyl or alkali metal and R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl, cycloalkylalkyl or lower alkenyl and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease and as antiinflammatory agents and analgesics.
Claims18
A compound of the structure ##STR61## including all stereoisomers thereof, wherein A is (CH.sub.2).sub.2, CH.dbd.CH or a single bond;
- B is a single bond or --CH.dbd.CH--;
- m is 1 to 8;
- n is 1 to 4;
- X is O or ##STR62## wherein n' is 0, 1 or 2;
- R is H, lower alkyl or alkali metal;
- and R.sup.1 is lower alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl or lower alkenyl.
The method as defined in claim 11 wherein said compound is administered in an amount within the range of from about 1 to about 100 mg/kg.
Dependencies are inferred from the claim text.