Back to results
US 4,542,144 AGranted
Anticonvulsant N-aryl-N'-(2-thiazolidinylidene)ureas
AssigneeMcNeilab, Inc.
InventorChris R. Rasmussen
Life of this patent
Estimating the term…
Abstract
N-aryl-N'-(2-thiazolidinylidene)urea compounds of Formula II ##STR1## wherein: R is CH.sub.3, C.sub.2 H.sub.5, or H; R.sub.1 is CH.sub.3, C.sub.2 H.sub.5, Cl, Br, F, CF.sub.3, OCH.sub.3 or H, provided that R.sub.1 is not H where R is H; R.sub.2 is CH.sub.3 or H, provided that R.sub.2 is not H when R is H; R.sub.3 is H or F or CH.sub.3 ; R.sub.4 is H or CH.sub.3 ; R.sub.5 is CH.sub.3, C.sub.2 H.sub.5, Cl, Br, F, CF.sub.3, OCH.sub.3, have anticonvulsant activity and are useful in the treatment of epilepsy.
Claims19
An N-aryl-N'-(2-thiazolidinylidene)urea derivative selected from the group consisting of:
- N-(2,6-dimethylphenyl)-N'-(3-methyl-2-thiazolidinylidene)urea,
- N-(2,6-dichlorophenyl)-N'-(3-methyl-2-thiazolidinylidene)urea,
- N-(2-methoxyphenyl)-N'-(3-methyl-2-thiazolidinylidene)urea,
- N-(2-trifluoromethylphenyl)-N'-(3-methyl-2-thiazolidinylidene)urea,
- N-(2,6-diethylphenyl)-N'-(3-methyl-2-thiazolidinylidene)urea,
- N-(2-ethyl-6-methylphenyl)-N'-(3methyl-2-thiazolidinylidene)urea,
- N-(2,5-dimethylphenyl)-N'-(3-methyl-2-thiazolidinylidene)urea,
- N-(2,4-dimethylphenyl)-N'-(3-methyl-2-thiazolidinylidene)urea,
- N-(2,3-dimethylphenyl)-N'-(3-methyl-2-thiazolidinylidene)urea,
- N-(2,4,6-trimethylphenyl)-N'-(3-methyl-2-thiazolidinylidene)urea,
- N-(2-chloro-6-methylphenyl)-N'-(3-methyl-2-thiazolidinylidene)urea.
- N-(2,6-difluorophenyl)-N'-(3-methyl-2-thiazolidinylidene)-urea,
- N-(2,6-dibromophenyl)-N'-(3-methyl-2-thiazolidinylidene)urea,
- N-(2,6-dibromo-4-fluorophenyl)-N'-(3-methyl-2-thiazolidinylidene)urea,
- N-(2,6-dimethoxyphenyl)-N'-(3-methyl-2-thiazolidinylidene)urea, and
- N-(2,6-dimethylphenyl)-N'-(2-thiazolidinylidene)urea.
13 more elements
Dependencies are inferred from the claim text.