Dioxobenzocyclo-hepta-pyridine compounds, process and use as antihypertensives
AssigneeMerck & Co., Inc.
InventorSteven D. Young
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Abstract
6H-3,11b-Dihydrocarbalkoxy-5,7-dioxobenzo[6,7]cyclohepta[1,2-c]pyridine compounds represented by the formula: ##STR1## wherein G is lower alkyl or halogen; R is lower alkyl, R' is hydrogen, lower alkyl, and n is from 0 to 2 and a process for their preparation are disclosed. The compounds have the property of inhibiting calcium induced contraction of the smooth muscle.
Claims5
A dioxobenzocycloheptapyridine compound represented by the formula ##STR8## wherein G is lower alkyl or halogen;
- R is lower alkyl, R' is hydrogen, lower alkyl, and n is from 0 to 2.
A process for preparing a dioxobenzocycloheptapyridine compound represented by the formula ##STR9## wherein G is lower alkyl or halogen, R is lower alkyl, R' is hydrogen or lower alkyl and n is from 0 to 2, which comprises intimately contacting an dihydropyridine compound of the formula ##STR10## wherein G, R and R' are as previously defined and R" is a lower alkyl group with a solution of trimethylaluminum in an inert solvent as reaction medium and in an inert atmosphere.
A composition useful in the treatment of hypertension comprising a non-toxic therapeutically active amount of a compound having the formula:
- ##STR11## wherein G is lower alkyl or halogen, R is lower alkyl, R' is hydrogen or lower alkyl and n is from 0 to 2, in initmate admixture with a pharmaceutically acceptable carrier.
A method for treating hypertension which comprises administering a non-toxic therapeutically active amount of a compound having the structure:
- ##STR12## wherein G is loweralkyl or halogen, R is lower alkyl, R' is hydrogen or lower alkyl and n is from 0 to 2, in an intimate admixture with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.