Alkylaminodesoxy-1.4;3.6-dianhydrohexitol nitrates substituted by purine bases and pharmaceutical compositions
AssigneeDr. Willmar Schwabe GmbH & Co.
InventorsKlaus Klessing, Shyam S. Chatterjee
Life of this patent
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Abstract
Alkylaminodesoxy-1.4;3.6-dianhydrohexitol nitrates substituted by purine bases of the general formula I, ##STR1## wherein R.sup.1 signifies a hydrogen atom or a lower alkyl group with 1 to 4 C-atoms, X a straight-chained or branched alkyl or hydroxyalkyl group with 1 to 7 C-atoms, Y a 1,3-dialkylxanthin-7-yl or a 3,7-dialkylxanthin-1-yl group, each with straight or branched-chained alkyl groups with 1 to 5 C-atoms, or an adenin-9-yl group, as well as their physiologically acceptable acid-addition salts. Process for the preparation of said compounds and pharmaceutical compositions containing said compounds.
Claims22
Alkylaminodesoxy-1.4;3.6-dianhydrohexitol nitrates substituted by purine bases having the formula ##STR16## wherein R.sup.1 signifies a hydrogen atom or lower alkyl with 1 to 4 C-atoms, X is a straight-chained, branched alkyl, or hydroxyalkyl, with 1 to 7 C-atoms, Y is 1,3-dialkylxanthin-7-yl, a 3,7-dialkylxanthin-1-yl group, each with straight or branched-chained alkyl groups having 1 to 5 C-atoms, and their physiologically acceptable acid-addition salts.
5-(3-Theophyllin-7-ylpropyl)-amino-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate.
5-(2-Theophyllin-7-ylethyl)-amino-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate.
5-(4-Theophyllin-7-ylbutyl)-amino-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate.
5-(5-Theophyllin-7-ylpentyl)-amino-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate.
5-(6-Theophyllin-7-ylhexyl)-amino-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate.
5-(2-Hy droxy-3-theophyllin-7-ylpropyl)-amino-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate.
5-[3 (3,7-Dimethylxanthin-1-yl)-propylamino]-5-desoxy-1.4;3.6-dianhydro-L-idito l 2-nitrate.
5-[3-(3- Isobutyl-1-methylxanthin-7-yl)-propylamino]-desoxy-1.4;3.6-dianhydro-L-idit ol 2-nitrate.
5-[N-Meth yl-N-(3-theophyllin-7-ylpropyl)-amino]-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate.
5-[1-Me thyl-3-(theophyllin-7-yl)-propylamino]-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate.
(+)-5-[ 1-Methyl-3-(theophyllin-7-yl)-propylamino]-5-desoxy-1.4:3.6-dianhydro-L-idi tol 2-nitrate.
(-)-5-[1-M ethyl-3-(theophyllin-7-yl)-propylamino]-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate.
5-[1-Me thyl-5-(theophyllin-7-yl)-pentylamino]-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate.
5-(3-Th eophyllin-7-ylpropyl)-amino-5-desoxy-1.4;3.6-dianhydro-D-glucitol 2-nitrate
2-(3-Theophyllin-7-ylpropyl)-amino-2-desoxy-1.4;3.6-dianhydro-D-glucito l 5-nitrate.
5-(3-The ophyllin-7-ylpropyl)-amino-5-desoxy-1.4;3.6-dianhydro-D-mannitol 2-nitrate.
Dependencies are inferred from the claim text.