Cardiac stimulating cyclic sulfonamido substituted 4-piperidino-quinazoline derivatives, compositions, and method of use therefor
AssigneePfizer Inc.
InventorsSimon F. Campbell, Albert A. Jaxa-Chamiec, David A. Roberts
Life of this patent
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Abstract
A series of novel 4-piperidino-6,7-dimethoxyquinazoline compounds, further substituted on the piperidino group, and the pharmaceutically-acceptable salts thereof, possess cardiac stimulating activity in mammals. They are useful in the curative or prophylactic treatment of cardiac conditions, in particular heart failure.
Claims17
A piperidinoquinazoline compound of the formula ##STR100## or a pharmaceutically acceptable salt thereof, wherein:
- X is an alkylene group of the formula ##STR101## where R is H, CH.sub.3 or C.sub.2 H.sub.5 ;
- Y is a group of the formula:
- ##STR102## where R.sup.1 is H or C.sub.1 -C.sub.4 alkyl, and R.sup.2 and R.sup.3 are each independently H or CH.sub.3 ;
- and either:
- (i) the piperidine ring is further substituted with a hydroxy group in the 3- or 4-position, and, if it is substituted with a hydroxy group in the 3-position, it can be further substituted in the same position with a C.sub.1 -C.sub.4 alkyl group;
- or
- (ii) the carbon atom of X attached to the piperidine ring is further substituted with a hydroxy group.
A method of stimulating the heart of a mammalian subject, which comprises administering to a mammalian subject in need of such treatment an effective heart stimulating amount of a piperidinoquinazoline compound of the formula ##STR115## or a pharmaceutically acceptable salt thereof, wherein:
- X is an alkylene group of the formula ##STR116## where R is H, CH.sub.3 or C.sub.2 H.sub.5 ;
- Y is a group of the formula:
- ##STR117## where R.sup.1 is H or C.sub.1 -C.sub.4 alkyl, and R.sup.2 and R.sup.3 are each independently H or CH.sub.3 ;
- and either:
- (i) the piperidine ring is further substituted with a hydroxy group in the 3- or 4-position, and, if it is substituted with a hydroxy group in the 3-position, it can be further substituted in the same position with a C.sub.1 -CHD 4 alkyl group;
- or
- (ii) the carbon atom of X attached to the piperidine ring is further substituted with a hydroxy group.
Dependencies are inferred from the claim text.