Antitumor compositions for non-injection administration
AssigneesYamasa Shoyu Kabushiki Kaisha, Mineo Saneyoshi
InventorsKenjiro Kodama, Akira Kuninaka, Mineo Saneyoshi
Life of this patent
Estimating the term…
Abstract
An antitumor composition comprising a pharmacologically effective quantity of an ester of 1-.beta.-D-arabinofuranosylcytosine-5'-phosphate represented by the general formula ##STR1## where R is a monovalent aliphatic hydrocarbon group having 14 to 23 carbon atoms, and A designates a hydrogen atom or a pharmaceutically-acceptable alkali cation, and a vehicle is effective when administered by a non-injection method, particularly orally.
Claims5
A method of inhibiting the growth of a malignant tumor treatable by ara-C in an animal which comprises administering orall to said animal a pharmacologically effective quantity sufficient to inhibit malignant tumors treatable by ara-C of an ester of 1-.beta.-D-arabinofuranosylcytosine-5'-phosphate represented by the formula ##STR3## wherein R is a monovalent aliphatic hydrocarbon group having 14 to 23 carbon atoms selected from the group consisting of tetradecyl, pentadecyl, cetyl, heptadecyl, stearyl, nonadecyl, eicosyl, heneicosyl, tricosyl, oleyl, linoleyl and palmitoleyl, and A represents a hydrogen atom or a pharmaceutically-acceptable alkali cation.
Dependencies are inferred from the claim text.