Long-lasting adhesive antifungal suppositories

In a suppository formulation which is substantially free of water and comprised of an antifungal agent selected from the group consisting of nystatin, amphotericin B, miconazole, ketoconazole, econazole or griseofulvin in an amount of from about 0.1 to about 6% by weight of the total formulation, and a suppository base, the improvement which comprises employed as said suppository base a substantially water-free base formulation which melts at body temperature, which suppository base formulation consists essentially of a combination of a cellulose polymer hydrocolloid or alkali metal salt thereof in an amount of from about 0.5 to about 10% by weight of the formulation, and a low-melting suppository base having a melting point of less than 95.degree. F., said cellulose polymer being selected from the group consisting of a cellulose either, a cellulose alkyl hydroxylate, a cellulose alkyl carboxylate or an alkali metal salt of a cellulose alkyl carboxylate or mixtures thereof, whereupon shortly after vaginal insertion of said suppository, said suppository base melts and releases said hydrocolloid and antifungal agent, and said hydrocolloid adheres to the vaginal membranes and retains said antifungal agent at the sites of infection.