Treatment of protein malnourished bacterially infected humans with LEM
OwnerLyle L. Moldawer, George L. Blackburn +1inventors
InventorsLyle L. Moldawer, George L. Blackburn, Bruce R. Bistrian
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Abstract
Exogenous LEM (Leukocyte Endogenous Mediator, also referred to as endogenous pyrogen) is parenterally administered to humans who are protein malnourished and are infected with bacteria, in order to preinitiate and then maintain the normal metabolic responses to the tissue damage occurring during infection, and thereby promote the normal metabolic response by the human.
Claims4
The method of stimulating metabolic function comprising treating a protein mainourished human who has a serum albumin less than about 3.2 gm/dl and who is bacterially infected by parenterally admistering to said human during said infection a sufficinet amount of LEM to supplement LEM being endogenously produced by said human and to raise the body temperature of the human above normal during at least some of the time the human is infected.
Dependencies are inferred from the claim text.