US 4,541,955 AGranted

Azetidinone-4-carboxylate containing a protected 3-acetyl group and process for their preparation

AssigneeRichter Gedeon Vegyeszeti Gyar Rt.

InventorsKaroly Lempert, Kalman Harsanyi, Gabor Doleschall, Gyula Hornyak, Jozsef Nyitrai, Karoly Zauer, Jozsef Fetter, Gyula Simig, Zsuzsanna Visky nee Gombos, Gizella Barta nee Szalai

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Abstract

The invention relates to new heterocyclic compounds containing a protected C-acetyl group. More particularly, the invention concerns new compounds of the Formula (V) ##STR1## wherein R is a group suitable for the protection of amides; Z is alkyl; and Y.sup.1 and Y.sup.2 together form a group suitable for temporary protection of a keto group. The new compounds are valuable intermediates in the synthesis of thienamycin.

Claims2

Dependent claims

A compound of the formula (V)

wherein
R is benzyl or benzyl substituted by one or two methoxy groups;
Z is methyl or ethyl;
and
Y.sup.1 and Y.sup.2 together with the carbon atom to which they are attached form together a 1,3-dioxolan-2-yl group or a thioanalog thereof.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application: 06/458,264Filed 17 Jan 1983 · continuation in part
Priority: HU 226315 Sep 1980
Granted: 17 Sep 1985
Term ends: Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07D 207/273
2-Pyrrolidones: with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or…
C07D 205/08
Having one double bond between ring members or between a ring member and a non-ring member: with one oxygen atom directly attached in position 2,…
C07D 405/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
C07D 411/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond