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US 4,541,954 AGranted
Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
AssigneeSmithKline Beckman Corporation
InventorsStanley J. Borowski, Thomas A. Post
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Abstract
A novel process for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine comprising cyclizing N-methyl-N-[2-(2'-chlorophenyl)ethyl]-2-chloroethylamine hydrochloride in a solution of trichlorobenzene and aluminum chloride.
Claims4
In the method of preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine comprising the step of reacting N-methyl-N-[2-(2'-chlorophenyl)ethyl]-2-chloroethylamine in the presence of a solution of an aluminum chloride catalyst, the improvement comprising using trichlorobenzene as the solvent.
Dependencies are inferred from the claim text.