Single-vessel process for preparing ring-substituted n-alkylanilines
AssigneeHoechst Aktiengesellschaft
InventorsKarl Sommer, Rudolf Schickfluss
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Abstract
Process for preparing ring-substituted N-alkylanilines of the formula (1) ##STR1## in which R.sub.1 and R.sub.2 each denote methyl or ethyl, in a single vessel, which comprises acylating m-nitroaniline in an excess of an aliphatic carbonyl compound of the formula (2) ##STR2## in which R.sub.1 is as defined above, with an acylating agent which contains the --CO--R.sub.2 acyl radical--which is transferred-- and reductively alkylating the resulting compound of the formula (3) ##STR3## in which R.sub.2 is as defined above, at temperatures of 120.degree.-160.degree. C. under a hydrogen pressure of 20-150 bar without intermediate isolation through the presence of an acid reaction promoter and of a nickel catalyst.
Claims5
A process for preparing ring-substituted N-alkylanilines of the formula (1) ##STR7## in which R.sub.1 and R.sub.2 each denote methyl or ethyl, in a single vessel, which comprises acylating m-nitroaniline in an excess of an aliphatic carbonyl compound of the formula (2) ##STR8## in which R.sub.1 is as defined above, with an acylating agent which contains the --CO--R.sub.2 acyl radical--which is transferred--and reductively alkylating the resulting compound of the formula (3) ##STR9## in which R.sub.2 is as defined above, at temperatures of 120.degree.-160.degree. C. under a hydrogen pressure of 20-150 bar without intermediate isolation through the presence of an acid reaction promoter and of a nickel catalyst.
Dependencies are inferred from the claim text.