Back to results
US 4,540,801 AGranted
5 Fluoro PGI compounds
AssigneeG. D. Searle & Co.
InventorsLeonard N. Nysted, Raphael Pappo
Life of this patent
Estimating the term…
Abstract
The present invention relates to 5-fluoro-PGI.sub.2 derivatives of Formula I. These compounds are useful for the treatment of platelet dysfunction. Also disclosed is the process for preparing them and the appropriate intermediates.
Claims5
A compound of formula I
- wherein R.sub.1 is:
- (a) OR.sub.2 ;
- (b) NR.sub.3 R.sub.4
- (c) ##STR10## or (d) ##STR11## wherein R.sub.2 is:
- (a) Na, K, or 1/2 Ca;
- (b) hydroxyalkyl of 1 to 6 C atoms;
- (c) hydrogen;
- or
- (d) alkyl of 1 to 6 carbon atoms wherein R.sub.3 is:
- (a) hydrogen;
- or
- (b) alkyl of 1 to 6 carbon atoms, inclusive;
- wherein R.sub.4 is:
- (a) hydrogen;
- or
- (b) alkyl of 1 to 6 carbon atoms, inclusive;
- wherein n is an integer from 4 to 5;
- wherein m and q are integers and taken together equal 4 to 5
- wherein Y is:
- (a) O
- (b) NH wherein X is:
- (a) ##STR12## or (b) ##STR13## wherein R.sub.5 is alkoxy from 1 to 6 carbon atoms and the individual isomers either alone or in combination;
- and the pharmacologically acceptable salts thereof.
20 more elements
Dependencies are inferred from the claim text.