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US 4,540,795 AGranted
Fluoronitroaralkyloxazolines, derivatives thereof, and nucleophilic substitution processes for preparing them
AssigneeEthyl Corporation
InventorKenneth C. Lilje
Life of this patent
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Abstract
Fluoronitroaralkyloxazolines are prepared by reacting a fluoronitroaromatic compound with an alpha-substituted 2-alkyloxazoline in an inert solvent and in the presence of a base. Fluoronitroaralkyloxazolines are useful intermediates for the synthesis of pharmaceuticals, such as flurbiprofen.
Claims3
A 2-(aminofluorobenzenealkyl)oxazoline corresponding to the formula:
- ##STR2## wherein R is halo or an alkyl group having not more than 10 carbons, and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently selected from hydrogen, methyl, and ethyl.
2-[1-(4-amino-3-fluorobenzene)ethyl]-4,4-dimethyloxazoline.
Dependencies are inferred from the claim text.