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US 4,540,780 AGranted
Diphenylmethylene piperidines
AssigneeWarner-Lambert Company
InventorsDavid A. Downs, Haile Tecle
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Abstract
Novel chemical compounds which are diphenylmethylene piperidine compounds are provided, as well as methods for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. The compounds have both anticholinergic and antidopaminergic properties, and are useful as antiemetic, antihistamine, pulmonary, antiallergy, and antispasmodic agents.
Claims3
Diphenylmethylene piperidine compounds having in the free base form the formula:
- ##STR59## and pharmaceutically acceptable salts thereof, where X and Y, which can be the same or different, are H, halogen, halomethyl, alkyl, or alkoxy;
- n is 2, 3, or 4;
- Z is O, CH.sub.2, S, single bond, .dbd.C-fluorophenoxy, .dbd.CHOH, .dbd.CHCH.sub.2 CH.sub.2 OH, .dbd.C(OH).sub.2, or NR.sub.4, R.sub.4 being H, alkyl, or aryl, and R.sub.1 and R.sub.2, which can be the same or different are hydrogen, alkyl, or an aromatic or hetero aromatic ring.
Dependencies are inferred from the claim text.