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US 4,540,779 AGranted
Crystalline 7-(R)-amino-3-(1'pyridiniummethyl)-ceph-3-em-4-carboxylate monohydrochloride monohydrate compound
AssigneeEli Lilly and Company
InventorsPreston C. Conrad, Alvydas A. Jarmas
Life of this patent
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Abstract
Crystalline 7-(R)-amino-3-(1'-pyridiniummethyl)-ceph-3-em-4-carboxylate monohydrochloride monohydrate compound is an intermediate in the synthesis of the cephalosporin antibiotic ceftazidime.
Claims1
The crystalline monohydrochloride monohydrate of 7-(R)-amino-3-(1'-pyridiniummethyl)-ceph-3-em-4-carboxylate which has the following X-ray powder diffraction obtained with nickel-filtered copper radiation of .lambda.=1.5418 .ANG. wherein d represents the interplanar spacing and I/I.sub.1 the relative intensity:
- ______________________________________ d I/I.sub.1 ______________________________________ 10.75 .47 8.17 1.00 6.31 .20 5.74 .33 5.35 .20 b 4.95 .13 4.84 .07 4.47 .93 4.25 .53 4.08 1.00 3.81 .20 3.67 .07 3.52 .33 3.44 .13 3.29 .07 3.14 .53 3.01 .27 2.90 .10 2.80 .47 2.74 .27 2.63 .07 2.53 .20 2.47 .07 2.41 .03 2.38 .27 2.27 .27 2.20 .10 2.11 .03 b 2.06 .03 b 1.992 .17 1.948 .07 1.893 .10 b 1.837 .13. ______________________________________
Dependencies are inferred from the claim text.