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US 4,540,702 AGranted
2-Substituted-4-thiazolidones
AssigneeKureha Kagaku Kogyo Kabushiki Kaisha
InventorsTakao Kawasaki, Tadashi Tsuchiya, Yoshiaki Osaka
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Abstract
Disclosed herein novel compounds, 2-substituted-4-thiazolidones having anti-peptic ulcer activity, and methods for producing the same.
Claims3
A 2-substituted-4-thiazolidone of the formula:
- ##STR17## wherein n' is an integer of 1 to 2.
A pharmaceutical composition in dosage unit form comprising
- a dosage effective for the treatment of peptic ulcer of a 2-substituted-4-thiazolidone of the formula:
- ##STR18## wherein n' is an integer of 1 or 2, and a pharmaceutically acceptable carrier.
A process for producing 2-substituted-4-thiazolidone represented by the general formula (I):
- ##STR19## wherein R represents methoxy-, ethoxy-, carboxyl-, methylenedioxy- or dimethylamino-, n is an integer of 1 to 3, and m is 0 or 1 comprising the steps of:
- (a) reacting a compound represented by the general formula (IV):
- ##STR20## wherein R, n and m represent the same as in the formula (I), with mercaptoacetic acidamide at a temperature of 10.degree. to 50.degree. C. to form an intermediate represented by the general formula (V):
- ##STR21## wherein R, n and m represent the same as in formula (I);
- (b) successively subjecting intermediate (V) to cyclization at a temperature of 50.degree. to 150.degree. C. thereby obtaining a compound according to formula (I).
2 more elements
Dependencies are inferred from the claim text.