Aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones, pharmaceutical compositions and use
AssigneeBASF SE
InventorsAlbrecht Franke, Josef Muller, Helmut Lietz, Walter-Wielant Wiersdorff, Hans-Gunther Hege, Claus D. Muller, Josef Gries, Dieter Lenke, Gerda von Philipsborn, Manfred Raschack
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Abstract
Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
Claims10
An aminopropanol derivative of the formula ##STR6## wherein R.sup.1 is n-propyl, isopropyl, cyclopropyl, 3-methoxyisopropyl or n-butyl, R.sup.2 is hydrogen or together with R.sup.1 and the nitrogen atom linking R.sup.1 and R.sup.2 form 4-methyl-piperazin-1-yl and R.sup.5 and R.sup.6 are methyl or ethyl or a physiologically acceptable acid addition thereof.
2-(2'-Hydroxy-3'-n-butylaminopropoxy)-.beta.-(4-dimethylaminophen yl)-propiophenone or a physiologically acceptable acid addition salt thereof.
2-[2'- Hydroxy-3'-(4-methyl-piperazin-1-yl)-propoxy]-5-methyl-.beta.-(4-dimethylam inophenyl)-propiophenone or a physiologically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.