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US 4,540,582 AGranted
Treatment of seizure disorders and pharmaceutical compositions useful therein
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsNikolaus Seiler, Shakir Sarhan
Life of this patent
Estimating the term…
Abstract
Glycine, sarcosine, or N,N-dimethylglycine exerts a synergistic effect upon gamma-vinyl GABA for the treatment of seizure disorders, in particular epilepsy.
Claims10
A method for controlling seizures in a patient in need thereof which comprises administering to said patient in combination:
- (a) from 0.2 to 2.0 grams per day of gamma-vinyl GABA, or a pharmaceutically acceptable salt thereof;
- and
- (b) from 2 to 12 grams per day of glycine, sarcosine N,N-dimethylglycine or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition in dosage unit form for controlling seizures in a patient in need thereof which comprises:
- (a) from 50 to 100 mg of gamma-vinyl GABA, or a pharmaceutically acceptable salt thereof,
- (b) from 250 to 500 mg of glycine, sarcosine, N,N-dimethylglycine, or a pharmaceutically acceptable salt thereof, and
- (c) a pharmaceutically acceptable carrier or diluent.
Dependencies are inferred from the claim text.