Topical nonsteroidal anti-inflammatory compositions and uses
AssigneeBristol-Myers Company
InventorsXina Nair, Davis L. Temple, Jr.
Life of this patent
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Abstract
New compositions using particular .beta..sub.2 agonists and vehicle materials have been prepared and are useful for producing a topical anti-inflammatory effect in mammals. The selected .beta..sub.2 agonists have previously not been known to exhibit topical antiinflammatory activity. The compositions can be for example in the form of sprays, ointments, creams, gels, lotions, and suppositories, all of which are to be applied to the mammal topically, as opposed to systemically.
Claims9
A method of reducing topical inflammation in a mammal in need thereof which comprises topically administering to said mammal an amount effective to produce a topical anti-inflammatory effect of a composition comprising
- (a) a compound of the formula ##STR10## wherein R.sup.1 and R.sup.2 are independently hydrogen or (lower)alkyl, provided that R.sup.1 and R.sup.2 cannot both be hydrogen;
- wherein M is phenyl, indole or hydrogen;
- wherein A is (--CH.sub.2 --).sub.n in which n is 0, 1 or 2;
- wherein B is (--CH.sub.2 --).sub.m in which m is 0, 1 or 2;
- and wherein R.sup.3 is ##STR11## and (b) a compatible, topically acceptable vehicle.
Dependencies are inferred from the claim text.