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US 4,540,575 AGranted
Choline oxidase inhibitor
AssigneeMerck & Co., Inc.
InventorsRichard L. Monaghan, Yu-Lin Kong
Life of this patent
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Abstract
New fermentation products useful in the treatment of tardive dyskinesia by inhibition of choline oxidase are produced by fermentation of a nutrient medium with a microorganism, Streptomyces hygroscopicus.
Claims6
Product with choline oxidase inhibitory activity produced by the controlled aerobic fermentation of an aqueous nutrient medium by Streptomyces hygroscopicus ATCC 39296 at a temperature range of 20.degree.-37.degree. C. for 3-5 days at pH 6.0 to 8.0.
Dependencies are inferred from the claim text.