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US 4,540,403 AGranted
Parenteral dispensing system with programmable drug administration
AssigneeAlza Corporation
InventorFelix Theeuwes
Life of this patent
Estimating the term…
Abstract
A parenteral delivery system is disclosed for administering a beneficial agent to an agent-receiving recipient. The parenteral system comprises an electrotransport apparatus that admits an agent at an electrically controlled rate into medical fluid that flows through the parenteral system over delivery time.
Claims30
A parenteral delivery system for administering a beneficial agent to a recipient, the delivery system comprising:
- I. a reservoir of a pharmaceutical fluid,
- II. an electrotransport apparatus for use with the parenteral system for admitting a beneficial agent into the pharmaceutical fluid, the electrotransport apparatus comprising:
- (a) a housing comprising a wall that surrounds an internal space;
- (b) means in the wall for (1) releasably connecting the electrotransport apparatus to the parenteral system, for (2) letting pharmaceutical fluid flow from the parenteral system with the electrotransport apparatus, and for (3) letting pharmaceutical fluid exit the electrotransport apparatus and reenter the parenteral system;
- (c) a pair of electrodes in spaced relation disposed within the electrotransport apparatus;
- (d) a cation exchange membrane interposed between the electrodes;
- and,
- (e) a beneficial agent in the housing initially present between an electrode and the cation exchange membrane.
5 more elements
A parenteral delivery system for administering a beneficial agent to a recipient, the delivery system comprising:
- I. a reservoir of a pharmaceutical fluid;
- II. an electrotransport apparatus for use with the parenteral system for admitting a beneficial agent into the pharmaceutical fluid, the electrotransport apparatus comprising:
- (a) a housing comprising a wall that surrounds an internal space;
- (b) an inlet in the wall for letting fluid from the parenteral system enter the electrotransport apparatus;
- (c) an outlet in the wall for letting fluid from the electrotransport apparatus exit the electrotransport apparatus and reenter the parenteral system;
- (d) a pair of electrodes in spaced-apart relation positioned within the electrotransport apparatus;
- (e) an anion exchange membrane interposed between the electrodes;
- and,
- (f) a beneficial agent in the housing between an electrode and the anion exchange membrane.
6 more elements
A parenteral delivery system for administering a beneficial agent to a recipient, the delivery system comprising:
- I. a reservoir of a pharmaceutical fluid;
- II. an electrotransport apparatus for use with the parenteral system for admitting a beneficial agent into the pharmaceutical fluid, the electrotransport apparatus comprising:
- (a) a housing comprising a wall that surrounds an internal lumen;
- (b) an inlet in the wall adapted for releasably connecting the electrotransport apparatus to the parenteral system;
- (c) an outlet in the wall adapted for connecting the electrotransport apparatus to the parenteral system;
- (d) a porous body in the housing, the porous body comprising a fluid entrance surface, a fluid exit surface, and being capable of carrying a surface charge;
- (e) a pair of electrodes in the housing placed on each side of the porous body;
- and,
- (f) a beneficial agent in the housing between an electrode and the fluid entrance surface of the porous body.
6 more elements
A parenteral delivery system for administering a beneficial agent to a recipient, the delivery system comprising:
- I. a reservoir of a pharmaceutical fluid;
- II. an electrotransport apparatus for use with the parenteral system for admitting a beneficial agent into the pharmaceutical fluid, the electrotransport apparatus comprising:
- (a) a housing comprising a wall that surrounds an internal lumen;
- (b) an inlet in the wall for connecting the electrotransport apparatus to the parenteral system;
- (c) an outlet in the wall for connecting the electrotransport apparatus to the parenteral system;
- (d) a pair of spaced electrodes within the lumen;
- (e) a porous body and an ion exchange member within the lumen and disposed between the electrodes, said body being capable of carrying a surface charge;
- (f) a fluid passageway in the lumen, said passageway extending from the inlet to the outlet and interposed between the porous body and the ion exchange member;
- and,
- (g) a beneficial agent in the lumen between the electrode, the porous body and the ion exchange member.
7 more elements
A parenteral delivery system for administering a beneficial agent to a recipient, wherein the parenteral system comprises:
- I. a primary path, said primary path comprising:
- (a) a reservoir of a medical fluid;
- (b) a drip chamber in fluid communication with the reservoir;
- and,
- II. a by-pass that circumvents the primary path and comprises means for releasably connecting thereto said by-pass comprising:
- (c) an electrotransport apparatus for admitting a beneficial agent into the medical fluid, the electrotransport apparatus comprising:
- (1) a housing comprising a wall that surrounds an internal space;
- (2) an inlet in the wall adapted for receiving fluid from the primary path;
- (3) an outlet in the wall adapted for returning fluid to the primary path;
- (4) a pair of electrodes in spaced-apart position within the lumen;
- (5) an ion exchange membrane interposed between the electrodes;
- and,
- (6) a beneficial agent in the lumen between the wall and the ion exchange membrane.
10 more elements
Dependencies are inferred from the claim text.