Anti-arrhythmic agents
AssigneeAmerican Home Products Corporation
InventorGeorge C. Buzby, Jr.
Life of this patent
Estimating the term…
Abstract
Compounds of the formula: ##STR1## in which Y is --(CH.sub.2).sub.n -- where n is one of the integers 1,2,3 or 4 or ##STR2## where R is hydrogen, alkyl, polyfluorinated alkyl, --CN, cyanoalkyl, cycloalkyl or cycloalkylalkyl; R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7, independently, are hydrogen, alkoxy, trifluoromethyl or halo; R.sup.8 is hydrogen or alkyl; R.sup.9 is alkyl; R.sup.10 is alkyl; m is one of the integers 0 or 1; p is one of the integers 0, 1, 2 or 3; and s is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof, are useful as anti-arrhythmic agents.
Claims17
A compound of the formula:
- ##STR8## in which Y is --(CH.sub.2).sub.n -- where n is one of the integers 1, 2, 3 or 4 or ##STR9## where R is hydrogen, alkyl of 1-6 carbon atoms, polyfluorinated alkyl of 1 to 6 carbon atoms, --CN, cyanoalkyl in which the alkyl moiety contains 1 to 3 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or cycloalkylalkyl of 4 to 8 carbon atoms;
- R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7, independently, are hydrogen, alkoxy of 1-3 carbon atoms, trifluoromethyl, --Cl, --Br or --F;
- R.sup.8 is hydrogen or alkyl of 1 to 6 carbon atoms;
- R.sup.9 is alkyl of 1 to 3 carbon atoms;
- R.sup.10 is alkyl of 1 to 3 carbon atoms;
- m is one of the integers 0 or 1;
- p is one of the integers 0, 1, 2 or 3;
- and
- s is one of the integers 0 or 1;
- or a pharmaceutically acceptable salt thereof, with the provisos that the sum of m, p and s must be 1, 2, 3 or 4;
- and the number of linear atoms in the bridge connecting the two aromatic rings does not exceed 8;
- and when n is 1 or 2, two of R.sup.2, R.sup.3 and R.sup.4 are other than hydrogen.
A compound of the formula:
- ##STR16## in which Z represents ##STR17## where R is alkyl of 1 to 4 carbon atoms;
- R.sup.4 R.sup.6 and R.sup.7 are alkoxy of 1 to 3 carbon atoms, trifluoromethyl, --Cl, --Br or F;
- and
- p is one of the integers 1 or 2;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.