Naphthalenyloxy substituted carboxylic acids
AssigneeHoffmann-La Roche Inc.
InventorRonald A. LeMahieu
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl, X is hydrogen or halogen, and A is the group ##STR2## wherein R.sub.1 is hydrogen, acyl or lower alkyl, R.sub.2 is hydrogen or lower alkyl, m is an integer from 2 to 4, n is an integer from 1 to 3, and t is an integer from 1 to 5, provided that R.sub.1 is adjacent to --(CH.sub.2).sub.m [O(CH.sub.2).sub.m ].sub.n O--, and, when R.sub.2 is hydrogen, salts thereof with pharmaceutically acceptable bases, are described. The compounds of formula I are useful as agents for the treatment of allergic conditions.
Claims11
A compound of the formula ##STR16## wherein R is hydrogen or lower alkyl, X is hydrogen or halogen, and A is the group ##STR17## wherein R.sub.1 is hydrogen, acyl or lower alkyl, R.sub.2 is hydrogen or lower alkyl, m is an integer from 2 to 4, n is an integer from 1 to 3, and t is an integer from 1 to 5, provided that R.sub.1 is adjacent to --(CH.sub.2).sub.m [O(CH.sub.2).sub.m ].sub.n O--, and, when R.sub.2 is hydrogen, a salt thereof with a pharmaceutically acceptable base.
A method of treating allergies which comprises administering to a host requiring such treatment an effective amount of a compound of the formula ##STR21## wherein R is hydrogen or lower alkyl, X is hydrogen or halogen, and A is the group ##STR22## wherein R.sub.1 is hydrogen, acyl or lower alkyl, R.sub.2 is hydrogen or lower alkyl, m is an integer from 2 to 4, n is an integer from 1 to 3, and t is an integer from 1 to 5, provided that R.sub.1 is adjacent to --(CH.sub.2).sub.m [O(CH.sub.2).sub.m ].sub.n O--, and when R.sub.2 is hydrogen, a salt thereof with a pharmaceutically acceptable base.
A pharmaceutical composition comprising a compound of the formula ##STR23## wherein R is hydrogen or lower alkyl, X is hydrogen or halogen, and A is the grooup ##STR24## wherein R.sub.1 is hydrogen, acyl or lower alkyl, R.sub.2 is hydrogen or lower alkyl, m is an integer from 2 to 4, n is an integer from 1 to 3, and t is an integer from 1 to 5, provided that R.sub.1 is adjacent to --(CH.sub.2).sub.m [O(CH.sub.2).sub.m ].sub.n O--, and when R.sub.2 is hydrogen, a salt thereof with a pharmaceutically acceptable base, and an inert pharmaceutical carrier.
Dependencies are inferred from the claim text.