1H-Cyclopenta[b]benzofuran derivative and its analog
OwnerMing L. King, Chin-Chih Chiang +4inventors
InventorsMing L. King, Chin-Chih Chiang, Han-Chin Ling, Masahito Ochiai, Eiichi Fujita, Andrew T. McPhail
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Abstract
Substantially pure compounds having the general formula ##STR1## wherein (1) ##STR2## R.sup.2 is .beta.-hydroxy and R.sup.3 and R.sup.4 together form an oxygen bridge, or (2) ##STR3## R.sup.2 and R.sup.3 together form an additional carbon-carbon bond, and R.sup.4 is hydroxy, are disclosed. These compounds exhibit antileukemic activity against P388 lymphocytic leukemia in CDF.sub.1 mice and inhibitory activity in vitro against cells derived from human epidermoid carcinoma of the nasopharynx(KB) cells.
Claims3
A substantially pure compound of the formula ##STR9## wherein ##STR10## R.sup.2 is .beta.-hydroxy and R.sup.3 and R.sup.4 together form an oxygen bridge, or ##STR11## R.sup.2 and R.sup.3 together form an additional carbon-carbon bond, and R.sup.4 is hydroxy.
A substantially pure compound of the formula ##STR12##
A substantially pure compound of the formula ##STR13##
Dependencies are inferred from the claim text.