Process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine
AssigneeUbe Industries, Ltd.
InventorsKozo Fujii, Keigo Nishihira, Hiroyuki Sawada, Shuji Tanaka, Mamoru Nakai, Hiroshi Yoshida, Teruhiko Inoue, Kiyosi Oomori
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Abstract
There is disclosed a process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine, which comprises subjecting a 2-alkyl-4-amino-5-formylpyrimidine to catalytic reaction with hydrogen and ammonia in the presence of a reduction catalyst. According to the process of this invention, the desired product can be obtained in much higher yield as compared with the processes known to the art.
Claims26
A process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine which comprises reacting a 2-alkyl-4-amino-5-formylpyrimidine or a salt of a mineral acid thereof with hydrogen and ammonia in an amount of at least 4 moles of ammonia per one mole of the 2-alkyl-4-amino-5-formylpyrimidine or salts thereof (a) in the presence of a reduction catalyst selected from the group consisting of palladium supported on activated carbon, nickel-diatomaceous earth, platinum supported on alumina, copperchromium powder and Raney nickel and (b) in the presence of at least one salt of divalent nickel or hydrate thereof.
A process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine which comprises reacting a 2-alkyl-4-amino-5-formylpyrimidine or salt thereof with ammonia in a first inert solvent to form a reaction product;
- reacting said reaction product, without isolating the same from the reaction mixture, with a second inert solvent containing ammonia, hydrogen and the reduction catalyst to reduce said reaction product and thereby obtain 2-alkyl-4-amino-5-aminomethylpyrimidine, said ammonia being in an amount of at least 4 moles of ammonia per one mole of the 2 alkyl-4-amino-5-formylpyrimidine or salts thereof, and said reduction catalyst being selected from the group consisting of palladium supported on activated carbon, nickel-diatomaceous earth, platinum supported on alumina, copper-chromium powder and Raney nickel.
A process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine which comprises simultaneously reacting (i) a 2-alkyl-4-amino-5-formylpyrimidine or a salt of a mineral acid thereof with (ii) hydrogen and (iii) ammonia in an amount of at least 4 moles of ammonia per one mole of the 2-alkyl-4-amino-5-formylpyrimidine or salts thereof in the presence of a reduction catalyst selected from the group consisting of palladium supported on alumina, copper-chromium powder and Raney nickel.
Dependencies are inferred from the claim text.