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US 4,539,399 AGranted
Bonded phase material for chromatographic separations
AssigneeAdvanced Separation Technologies Incorporated
InventorDaniel W. Armstrong
Life of this patent
Estimating the term…
Abstract
A highly selective bonded phase material useful to separate a wide variety of organic and inorganic substances by thin layer chromatography (TLC), liquid chromatography (LC) or high performance liquid chromatography (HPLC) is produced by bonding a cyclodextrin to a silica gel by means of a specific silane linkage. The preparation of such materials and their uses are described.
Claims14
The process of producing an improved chromatographic separation material which comprises:
- (a) providing a silica gel in particle form;
- (b) reacting said silica gel with a silane having between two and twenty carbon atoms in the chain length thereof to produce a product with an active terminal group;
- (c) further reacting the active terminal group of said product with an active primary or secondary hydroxyl group or groups of a cyclodextrin, whereby said cyclodextrin is chemically bonded to said silica gel by said silane.
Dependencies are inferred from the claim text.