Dihydropyridine derivatives and their use in treating heart conditions and hypertension

A 1,4-dihydropyridine derivative of the formula:

• ##STR81## , or a pharmaceutically acceptable acid addition salt thereof, where R is aryl or heteroaryl;
• R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.4 alkyl or 2-methoxyethyl;
• Y is --(CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 --, --CH.sub.2 CH(CH.sub.3)-- or --CH.sub.2 C(CH.sub.3).sub.2 --;
• R.sup.3 is hydrogen or is selected from the group consisting of:
• (a) ##STR82## where R.sup.4 is H, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, --COO(C.sub.1 -C.sub.4 alkyl), --CH.sub.2 COO(C.sub.1 -C.sub.4 alkyl), aryl, --SO.sub.2 aryl, or heteroaryl,
• and X is O or S;
• (b) ##STR83## (c) ##STR84## where R.sup.5 is 1-pyrrolidinyl, --NH.sub.2, --NH(C.sub.1 -C.sub.4 alkyl), --N(C.sub.1 -C.sub.4 alkyl).sub.2, or --NH(CH.sub.2).sub.2 N(C.sub.1 -C.sub.4 alkyl).sub.2 ;
• (d) ##STR85## where R.sup.6 is C.sub.1 -C.sub.4 alkyl or aryl;
• (e) ##STR86## where R.sup.7 is --CONH(C.sub.1 -C.sub.4 alkyl) or --COO(C.sub.1 -C.sub.4 alkyl);
• (f) ##STR87## (g) ##STR88## where R.sup.8 is --CN, --SO.sub.2 (C.sub.1 -C.sub.4 alkyl) or --SO.sub.2 aryl;
• (h) --CH.sub.2 CO.R.sup.9 where R.sup.9 is --NH.sub.2, --NH(C.sub.1 -C.sub.4 alkyl), --NH.aryl or C.sub.1 -C.sub.4 alkoxy;
• (i) --SO.sub.2.R.sup.10 where R.sup.10 is --NH.sub.2, --N(C.sub.1 -C.sub.4 alkyl).sub.2 or C.sub.1 -C.sub.4 alkyl;
• and
• (j) --CO.R.sup.11 where R.sup.11 is H, halomethyl, --COO(C.sub.1 -C.sub.4 alkyl), --CH.sub.2 O(C.sub.1 -C.sub.4 alkyl), --CH.sub.2 CO(C.sub.1 -C.sub.4 alkyl), C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, aryl, heteroaryl, morpholino or 5-oxo-pyrrolidin-2-yl;
• wherein the aryl is phenyl;
• phenyl substituted by one or two substituents selected from the group consisting of nitro, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, trifluoromethyl, (C.sub.1 -C.sub.4 alkoxy)carbonyl and cyano;
• 1-naphthyl;
• or 2-naphthyl;
• and
• wherein the heteroaryl is benzofuranyl;
• benzothienyl;
• pyridyl;
• pyridyl substituted by methyl or cyano;
• quinolyl;
• benzoxazolyl;
• benzthiazolyl;
• furyl;
• pyrimidinyl;
• thiazolyl;
• 2,1,3-benz-oxadiazol-4-yl;
• 2,1,3-benzthiadiazol-4-yl;
• thienyl;
• or thienyl substituted by halo or C.sub.1 -C.sub.4 alkyl.