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US 4,539,321 AGranted
5-Diaza-aryl-3-substituted pyridone compounds
AssigneeWilliam H. Rorer, Inc.
InventorHenry F. Campbell
Life of this patent
Estimating the term…
Abstract
5-Diaza-aryl-3-substituted-2-pyridone compounds useful for increasing cardiac contractility, pharmaceutical compositions and a method for the treatment of congestive heart failure comprising the use of said compounds.
Claims18
A compound according to the formula ##STR7## wherein:
- R.sub.1 is hydrogen, lower alkyl, hydroxyloweralkyl or phenloweralkyl;
- R.sub.3 is lower alkyl, cyano, guanidino, thioureido, ureido, carboxyl, lower alkoxy, hydroxyl, hydroxy loweralkyl, loweralkyl acylamino, carbamoyl, carbamoyl guanidino, or cyanoguanidino;
- R.sub.4 and R.sub.6 are each independently hydrogen or lower alkyl;
- R.sub.5 is a 6 membered ring heteroaryl group including at least two nitrogen atoms and four carbon atoms in the ring;
- and, wherein:
- one of the heteroaryl hydrogen atoms may be substituted by halo, lower alkyl, halo loweralkyl, hydroxy loweralkyl, hydroxy, lower alkylamino, dilower alkylamino, amino, loweralkyl acylamino, lower alkanoyl, cyano or nitro;
- or a pharmaceutically acceptable salt thereof.
4 more elements
A compound according to the formula ##STR9## wherein:
- R.sub.1 is lower alkyl;
- R.sub.3 is cyano;
- R.sub.4 and R.sub.6 are hydrogen or loweralkyl;
- R.sub.5 is pyrazinyl, pyrimidinyl, pyridazinyl, or pyrazinyl, pyrimidinyl or pyridazinyl subsituted in one position by lower alkyl, halo, haloloweralkyl, hydroxyloweralkyl, hydroxy, loweralkylamino, diloweralkylamino, amino, loweralkylacylamino, lower alkanoyl, cyano, or nitro;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.