Amidine derivatives
AssigneeBeecham Group Limited
InventorsPeter M. Newsome, Noel A. Mullan, John P. Marshall
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I) ##STR1## and acid addition salts thereof, wherein R.sup.1 is hydrogen, hydroxy, alkoxy, aryloxy, aralkoxy, heteroaryloxy or heteroaralkoxy; and one of R.sup.2, R.sup.3 and R.sup.4 is hydrogen and the others are the same or different and each is hydrogen, alkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; or R.sup.2 is hydrogen and ##STR2## is mono- or bi-cyclic amino, inhibit enterotoxin-induced secretion into the small intestine and are, therefore, useful in treating enterotoxin induced diarrhoea in humans and scours in animals.
Claims16
A compound of formula (I) ##STR14## or an acid addition salt thereof, wherein R.sup.1 is hydrogen, hydroxy, alkoxy, cyclic alkoxy, aryloxy or aryl C.sub.1-6 alkyloxy wherein the aryl moiety is phenyl or naphthyl, or heteroaryloxy or heteroaryl C.sub.1-6 alkyloxy wherein the heteroaryl moiety is a mono- or fused bicyclic aromatic group containing up to 4 heteroatoms selected from oxygen, nitrogen or sulphur;
- and
- one of R.sup.2, R.sup.3 and R.sup.4 is hydrogen and the others are the same or different and each is hydrogen, alkyl, cyclic alkyl, aryl or aryl C.sub.1-6 alkyl wherein the aryl group is phenyl or naphthyl or
- R.sup.2 is hydrogen and ##STR15## is mono- or bicyclic amino.
Dependencies are inferred from the claim text.