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US 4,539,318 AGranted
Tertiary aminohydroxypropoxy substituted thiadiazoles, pharmaceutical compositions and use
AssigneeMerck & Co., Inc.
InventorsJohn J. Baldwin, Gerald S. Ponticello
Life of this patent
Estimating the term…
Abstract
Novel tertiary aminohydroxypropoxy substituted thiadiazole compounds exhibit .alpha..sub.1 -adrenoceptor and serotonin antagonism and are also useful as antihypertensive agents.
Claims5
A compound of structural formula:
- ##STR39## or a pharmaceutically acceptable salt thereof wherein:
- R and R.sup.1 are independently:
- (1) C.sub.1-8 alkyl, either straight or branched chain,
- (2) R and R.sup.1 are joined together directly to form, with the nitrogen to which they are attached, pyrrolidino or piperidino, or through a heteroatom selected from O, N-(C.sub.1-3 alkyl) and S to form a six-membered heterocycle;
- Q is >N- or ##STR40## and R.sup.2 is
- (1) a carbocycle or heterocycle of 6 nuclear atoms, 0, 1 or 2 of which can be nitrogen atoms and either unsubstituted or substituted with
- (i) C.sub.1-3 alkyl,
- (ii) hydroxy,
- (iii) halo,
- (iv) cyano, or
- (v) C.sub.1-3 alkoxy.
8 more elements
Dependencies are inferred from the claim text.