(2'-5')-Oligo (3'-deoxyandenylate) and derivatives thereof
AssigneeResearch Corporation
InventorsRobert J. Suhadolnik, Joseph M. Wu, Paul Doetsch, Earl E. Henderson
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Abstract
3'-deoxyadenosine 5'-triphosphate is oligomerized to form (2'-5')-oligo (3'-deoxyadenylate) by incubation with adenosine triphosphate: (2'-5')-oligo adenosine adenyl transferase, in the presence of an inert support carrying a double stranded polynucleotide. The (2'-5')-oligo (3'-deoxyadenylate) is digested with a suitable phosphatase to remove the terminal phosphate groups. The thus produced corresponding 3'-deoxyadenosine compound is an anti-viral material effective against Herpes simplex infection and effective in inhibiting the transformation of cells infected with Epstein Barr virus.
Claims6
An anti-viral composition effective against Herpes simplex virus which comprises an effective amount of a compound of the formula ##STR2## wherein m is 0,1,2 or 3 and n is 0,1,2,3 or 4, and a pharmaceutically acceptable carrier.
An anti-viral composition effective against Herpes Simplex virus which comprises an effective amount of a compound selected from the group consisting of:
- 3'-Deoxyadenylyl-(2'-5')3'-deoxyadenylyl-(2'-5') b 3'-deoxyadenosine triphosphate,
- 3'-Deoxyadenylyl-(2'-5')3'-deoxyadenylyl-(2'-5')3'-deoxyadenosine diphosphate,
- 3'-Deoxyadenylyl-(2'-5')3'-deoxyadenylyl-(2'-5')3'-deoxyadenosine phosphate, and
- 3'-Deoxyadenylyl-(2'-5')3'-deoxyadenylyl-(2'-5')3'-deoxyadenosine.
Dependencies are inferred from the claim text.