Topical compositions containing copper (II) complexes of 3,5-dioxo-pyrazolidine derivatives and methods of combatting inflammation with them
AssigneeAlcusal Incorporated Pty. Ltd.
InventorsBarry Boettcher, William R. Walker
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Abstract
Novel copper (II) coordination complexes of 3,5-dioxo-pyrazolidine derivatives with dimethylsulphoxide, dimethylformamide, and 1,4-dioxan coordination ligands are described. The complexes are potent anti-inflammatory agents and are usually applied topically in non-aqueous solution, showing good dermal penetration and systemic absorption.
Claims8
An anti-inflammatory composition for topical application which comprises a compound of formula (III) ##STR4## wherein X is H, OH, halo or C.sub.1 -C.sub.10 alkyl and
- R is H or C.sub.1 -C.sub.10 alkyl
- dissolved in a pharmaceutically acceptable non-aqueous lipophilic solvent enabling dermal penetration.
A method of combatting inflammation which comprises topically administering to a human or animal patient a copper complex of the formula (III) ##STR5## wherein X is H, OH, halo or C.sub.1 -C.sub.10 alkyl and
- R is H or C.sub.1 -C.sub.10 alkyl
- dissolved in a pharmaceutically acceptable non-aqueous lipophilic solvent enabling dermal penetration.
Dependencies are inferred from the claim text.