Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
AssigneeScripps Clinic and Research Foundation
InventorsMichael G. Goodman, William O. Weigle
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Abstract
Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.
Claims20
A method of modulating animal cellular response comprising contacting animal cells with a composition suitable for modulating an immune response and including as an active ingredient an effective amount of 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain, said guanine derivative being free of electrically charged functionality, said 8-substituent having an electron withdrawing inductive effect greater than that of hydrogen and containing less than about 15 atoms, wherein said 8-substituent is selected from the group consisting of halo, mercapto, acyl mercapto, alkyl sulfido, nitro, cyano, keto, halomethyl, and methyleneoxy alkyl together with a diluent amount of a physiologically tolerable carrier.
A method of modulating immune response comprising contacting leucocytes with an immune modulating composition including as an active ingredient an effective amount of an 8-halo guanosine together with a diluent amount of a physiologically tolerable carrier.
A method of modulating immune response comprising contacting leucocytes with an immune modulating composition including as an active ingredient an effective amount of 8-mercapto guanosine together with a diluent amount of a physiologically tolerable carrier.
A method of modulating immune response comprising contacting leucocytes with an immune modulating composition including as an active ingredient an effective amount of 8-bromoguanosine together with a diluent amount of a physiologically tolerable carrier.
A method of modulating immune response comprising contacting leucocytes with an immune modulating composition including as an active ingredient an effective amount of 8-bromo-2',3',5'-tri-O-acetyl guanosine together with a diluent amount of a physiologically tolerable carrier.
A method of modulating immune response comprising contacting leucocytes with an immune modulating composition including as an active ingredient an effective amount of 8-bromo-2'-O-methyl guanosine together with a diluent amount of a physiologically tolerable carrier.
A method of modulating immune response comprising contacting leucocytes with an immune modulating composition including as an active ingredient an effective amount of 8-bromo-2'-deoxyguanosine together with a diluent amount of a physiologically tolerable carrier.
Dependencies are inferred from the claim text.