US 4,539,155 A · New peptide, process for preparation thereof and use thereof

New peptide, process for preparation thereof and use thereof

AssigneeFuisawa Pharmaceutical Company, Ltd.

InventorsYoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka

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Abstract

The invention relates to compounds and salts of compounds which are diaminopimelyl peptides, N-acetoxypropionyl or N-t-butoxycarbonyl-amino-acid - (.alpha.-OBzl) glutamic acid peptides or N-acylated derivatives of (.alpha.-OBzl) glytamic acid or of (.alpha.-OBzl) aminoadipic acid. The compounds and their salts are starting materials for the preparation of pharmacologically active peptides.

Claims3

Dependent claims

A compound of the formula or its salt:

##STR704## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy)-lower alkyl or ar(carboxy or protected carboxy)-lower alkyl whose aryl moiety may be substituted by hydroxy,
R.sub.b.sup.2 is hydrogen or lower alkyl,
R.sup.r is hydrogen or amino protective group, and
R.sup.q is carboxy or protected carboxy, provided that when R.sub.b.sup.2 is hydrogen,
then R.sub.a.sup.2 is mono- or di-carboxy lower alkyl having 1 and 3 to 6 carbon atoms, --CH.sub.2 CH.sub.2 COOH or ar(carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

06/515,590Filed 21 Jul 1983 · division

Priority

13 Nov 1979

Granted

3 Sep 1985

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07C 243/00
Compounds containing chains of nitrogen atoms singly-bound to each other
C07K 5/0215
Containing at least one abnormal peptide link: containing natural amino acids, forming a peptide bond via their side chain functional group, e.g.…
C07K 9/005
The peptide sequence having less than 12 amino acids and not being part of a ring structure: containing within the molecule the substructure…
C12N 1/205
Bacteria; Culture media therefor: bacterial isolates

Family

Serial093,523Parent of this continuation-in-part · filed 13 Nov 1979

Serial110,020Parent of this continuation-in-part · filed 7 Jan 1980

Serial147,710Parent of this continuation-in-part · filed 8 May 1980

Serial149,441Parent of this continuation-in-part · filed 13 May 1980

Serial171,024Parent of this continuation-in-part · filed 22 Jul 1980

Serial201,241Parent of this continuation-in-part · filed 27 Oct 1980

Serial229,072Parent of this division · filed 28 Jan 1981

US 4,311,640 AParent of this continuation-in-part · filed 19 Jan 1982

Serial377,841Parent of this division · filed 13 May 1982

4349466Parent of this division

4322341Parent of this continuation-in-part

US 4,539,155 AThis patent

From the US filing history. Foreign family members aren’t listed.