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US 4,537,981 AGranted
7-Oxabicycloheptane and 7-oxabicycloheptene compounds
AssigneeE. R. Squibb & Sons, Inc.
InventorsDavid L. Snitman, Martin F. Haslanger, Peter W. Sprague
Life of this patent
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Abstract
7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
Claims27
A compound having the structural formula ##STR53## and including all stereoisomers thereof;
- wherein A and B may be the same or different and A is CH.dbd.CH or (CH.sub.2).sub.2,
- B is CH.dbd.CH, C.tbd.C, or (CH.sub.2).sub.2 ;
- m is 1 to 8;
- X is CO.sub.2 R.sup.1 wherein R.sup.1 is H or lower alkyl;
- Y is aryl-lower alkyl;
- alkenyl containing 3 to 6 carbons;
- alkynyl containing 3 to 6 carbons;
- cycloalkyl;
- substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl or phenoxymethyl;
- wherein alkyl or lower alkyl by itself or as part of another group contains 1 to 12 carbons and may include as substituents halo, lower alkoxy, alkyl-aryl, haloalkyl, cycloalkyl or alkylcycloalkyl;
- cycloalkyl by itself or as part of another group contains 3 to 12 carbons in the ring portion, and may include as substituents 1 or 2 halogens, 1 or 2 lower alkyl groups or 1 or 2 lower alkoxy groups;
- aryl by itself or as part of another group refers to a monocyclic or bicyclic aromatic ring which contains 6 to 10 carbons in the ring portion, which may include as a substituent lower alkyl, halogen or lower alkoxy, which substituents will not be adjacent sterically hindered groups;
- and represents a single bond or double bond, with the proviso that where represents a double bond, A is CH.dbd.CH and B is CH.dbd.CH or (CH.sub.2).sub.2 and Y is other than alkenyl or alkynyl.
10 more elements
Dependencies are inferred from the claim text.