Loading patent…
AssigneeKali-Chemie Pharma GmbH
InventorsHenning Heinemann, Daniel Jasserand, Wolfgang Milkowski, Dimitri Yavordios, Horst Zeugner
Estimating the term…
Compounds corresponding to the formula: ##STR1## wherein R.sub.1 and R.sub.3 each represent hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; R.sub.2 and R.sub.4 each represent hydrogen, halogen, lower alkyl or lower alkoxy; Z represents an alkylene radical with 2 to 6 carbon atoms and Y" is halogen, hydroxyl, lower alkanesulphonyl, benzenesulphonyl, or lower alkyl or halogen substituted benzenesulphonyl, and acid addition salts thereof, with the proviso the Y" is other than chlorine if R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each are hydrogen and Z is ethylene or propylene. The claimed compounds are useful intermediates in the synthesis of 1-phenyl-2-[(4-substituted piperazinyl) alkyl]-1,2-dihydro-3H-indazol-3-ones which exhibit antiallergic activity.
A compound of the formula II ##STR15## where R.sub.1 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy, or trifluoromethyl radical, R.sub.2 is a hydrogen or halogen atom, or a lower alkyl or lower alkoxy radical, R.sub.3 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy or trifluoromethyl radical, R.sub.4 is a hydrogen or halogen atom, or a lower alkyl or lower alkoxy radical, Z is an alkylene radical with 2 to 6 carbon atoms and Y" is a halogen atom, or a hydroxyl, lower alkanesulphonyl, benzenesulfonyl or benzenesulphonyl radical which is substituted in the benzene ring by a lower alkyl radical or a halogen atom, or an acid addition salt thereof, with the proviso that Y" is other than chlorine if the substituents R.sub.1, R.sub.2, R.sub.3, and R.sub.4 each are hydrogen and Z is an ethylene or propylene group.
Dependencies are inferred from the claim text.