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US 4,537,967 AGranted
1-Oxo-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid derivatives
AssigneeWakamoto Pharmaceutical Co., Ltd.
InventorsKoohei Nozawa, Toyokichi Yoshizawa, Toshio Kuroda
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Abstract
The following new isocarbostyryl derivatives represented by the general formula [I]: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group, are provided, said derivatives having excellent angiotensin converting enzyme inhibitory activity with expectations therefore being as a hypotensor, and prepared by solvolysis of a compound of the following general formula [II]: ##STR2## wherein R.sub.1 is the same as defined above, R.sub.2 is an acyl group, and R.sub.3 is a hydrogen atom, an alkyl group or an aralkyl group.
Claims3
A compound of the following general formula [I]:
- ##STR7## wherein R.sub.1 represents a hydrogen atom or a lower alkyl group, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.