Substituted 1,3,4-thiadiazolo[3,2-A]pyrimidines and compositions containing them
AssigneeFarmitalia Carlo Erba S.p.A.
InventorsGianfederico Doria, Carlo Passarotti, Ada Buttinoni
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Abstract
Compounds of the formula (I) ##STR1## wherein R.sub.1 is (a) hydrogen or halogen; (b) a C.sub.1 -C.sub.6 alkyl group, unsubstituted or substituted by C.sub.1 -C.sub.4 alkoxy or by halogen; (c) a phenyl ring unsubstituted or substituted by a group chosen from halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy; (d) a C.sub.1 -C.sub.6 alkylthio group; R.sub.2 is hydrogen or halogen; R.sub.3 is 2-pyridyl, 3-pyridyl or 4-pyridyl, wherein each pyridyl group is unsubstituted or substituted by C.sub.1 -C.sub.4 alkyl; and the pharmaceutically acceptable salts thereof. The compounds possess anti-ulcerogenic and gastric anti-secretory activity.
Claims3
A compound of formula (I) ##STR14## wherein R.sub.1 is
- (a) hydrogen or halogen;
- (b) a C.sub.1 -C.sub.6 alkyl group, unsubstituted or substituted by C.sub.1 -C.sub.4 alkoxy or by halogen;
- (c) a phenyl ring unsubstituted or substituted by a group chosen from halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy;
- (d) a C.sub.1 -C.sub.6 alkylthio group;
- R.sub.2 is hydrogen or halogen;
- R.sub.3 is 2-pyridyl, 3-pyridyl or 4-pyridyl, wherein each pyridyl group is unsubstituted or substituted by C.sub.1 -C.sub.4 alkyl;
- and the pharmaceutically acceptable salts thereof.
A compound selected from the group consisting of:
- 2-phenyl-7-trans-[2-(3-pyridyl)-ethenyl]-5H-1,3,4-thiadiazolo[3,2-a]pyrimid ine-5-one;
- 7-trans-[2-(3-pyridyl)-ethenyl]-5H-1,3,4-thiadiazolo[3,2-a]pyrimidine-5-one ;
- and
- 2-methyl-7-trans-[2-(3-pyridyl)-ethenyl]-5H-1,3,4-thiadiazolo[3,2-a]pyrimid ine-5-one;
- and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.